Nichani P, Lazer T, Power J, Behrouzi B, Gauthier-Fisher A, Kenigsberg S, Librach CL
Sunnybrook Research Institute Research Day, Toronto, Canada
Publication year: 2015

LIFR-α expression was found to be a significant indicator of undifferentiated cells in human ovarian granulosa cells (GCs) collected via transvaginal ultrasound-guided oocyte retrieval during IVF. Up-regulation of LIFR-α in patients with high ovarian reserve and down-regulation of LIFR-α in patients with low ovarian reserve was observed. This novel finding may allow for the development of in-vitro follicle maturation protocols for fertility restoration strategies and have implications in regenerative medicine.